New stimuli responsive smart hydrogels open door to future material biology and biomedical applications
Prof Solar Fei and the brand new protein-based hydrogel developed by his workforce.
Credit score: Picture Copyright: HKUST
A analysis workforce led by Prof SUN Fei, Assistant Professor of Chemical & Organic Engineering at The Hong Kong College of Science and Expertise (HKUST), has created a brand new protein-based stimuli-responsive good hydrogel that might open doorways for future materials biology and biomedical functions.
Hydrogels, also called mushy matter within the medical world, are main supplies for biomedical functions equivalent to drug supply and stem cell remedy. However conventional hydrogels, utilized in merchandise equivalent to facial masks and speak to lenses, are made up of both artificial polymers or organic extracts equivalent to animal collagen, are more likely to trigger allergy symptoms. They can't totally mimic the complicated organic atmosphere wanted for cell progress and improvement.
Not solely is the brand new good hydrogel developed by Prof Solar's workforce appropriate to behave as a service for stem cells that are key parts for regenerative drugs, but additionally can management the time and method relating to drug supply inside human physique because of its mild sensing perform.
To create this novel hydrogel, the workforce assembled genetically-engineered proteins into molecular networks by stitching collectively the photoreceptor C-terminal adenosylcobalamin binding area (CarHC) proteins at room temperature. The synthesis depends solely on bacterial culturing -- a course of much like fermentation. The composition of the ensuing hydrogel resembles that of human tissues and thus can be utilized to ship stay cells into human our bodies whereas probably minimizing allergy symptoms and physique rejection. As a drug service, this photo-responsive hydrogel can shortly change from stable to liquid upon mild publicity, thus permitting medication to be launched into the physique in a managed method. The technique of making fully protein-based hydrogels represents a brand new approach to design bioactive supplies with exact management over their properties.
The analysis findings had been printed within the journal PNAS on June 6, 2017.
"Demand for good hydrogels is rising, the direct meeting of stimuli-responsive proteins into hydrogels opens up huge alternatives not only for future materials biology, but additionally medical therapy." Prof Solar stated. "In idea, hydrogels can function carriers for stem cells in regenerative drugs to advertise the therapeutic of broken organs, which implies organ transplantation might not be sufferers' solely resolution sooner or later."
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Not solely is the brand new good hydrogel developed by Prof Solar's workforce appropriate to behave as a service for stem cells that are key parts for regenerative drugs, but additionally can management the time and method relating to drug supply inside human physique because of its mild sensing perform.
To create this novel hydrogel, the workforce assembled genetically-engineered proteins into molecular networks by stitching collectively the photoreceptor C-terminal adenosylcobalamin binding area (CarHC) proteins at room temperature. The synthesis depends solely on bacterial culturing -- a course of much like fermentation. The composition of the ensuing hydrogel resembles that of human tissues and thus can be utilized to ship stay cells into human our bodies whereas probably minimizing allergy symptoms and physique rejection. As a drug service, this photo-responsive hydrogel can shortly change from stable to liquid upon mild publicity, thus permitting medication to be launched into the physique in a managed method. The technique of making fully protein-based hydrogels represents a brand new approach to design bioactive supplies with exact management over their properties.
The analysis findings had been printed within the journal PNAS on June 6, 2017.
"Demand for good hydrogels is rising, the direct meeting of stimuli-responsive proteins into hydrogels opens up huge alternatives not only for future materials biology, but additionally medical therapy." Prof Solar stated. "In idea, hydrogels can function carriers for stem cells in regenerative drugs to advertise the therapeutic of broken organs, which implies organ transplantation might not be sufferers' solely resolution sooner or later."
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