ONC201 may inhibit cancer stem cell self-renewals by altering their gene expression
Cancer stem cells survive after chemotherapy and radiation treatment and are associated with recurrence, metastasis and poor survival in clinical trials. Previous studies have shown that a small molecule known as ONC201 currently in advanced cancer clinical trials, targets self-renewing colorectal cancer stem cells. However, little is known about the specific stem cell-related effects by which ONC201 inhibits cancer stem cells from renewing. Prabhu and colleagues conducted a gene expression analysis of colorectal, prostate cancer and glioblastoma cell lines and patient-derived tissues that were both treated with ONC201. They found that ONC201 alters the gene expression of cancer stem cell markers and signaling pathways prior to killing the tumor cells, providing pharmacodynamic biomarkers of response. These changes were not observed in cells with acquired resistance to ONC201. Finally, the authors suggest that a pre-treatment gene expression signature of cancer stem cells might be ...