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Weian Zhao, associate professor of pharmaceutical sciences , and colleagues have programmed human bone marrow stem cells to identify the unique physical properties of cancerous tissue. They added a piece of "code" to their engineered cells so that they can detect distinctively stiff cancerous tissue, lock into it and activate therapeutics. In a study appearing in  Science Translational Medicine , the researchers report they have effectively and safely employed this stem cell-targeting system in mice to treat metastatic breast cancer that had spread to the lung. They first transplanted the engineered stem cells to let them find and settle into the tumor site where they secreted enzymes called cytosine deaminase. The mice were then administered an inactive chemotherapy called prodrug 5-f lurocytosine, which was triggered into action by the tumor site enzymes. Zhao said his team specifically focused on metastatic cancer, which comes when the disease spreads to other part...

Chromosomes (blue) have protective end caps called telomeres that help them maintain stability. In this image, the telomeres (green) are abnormally short, which leads to DNA damage that accrues over time. Using the gene editing technology CRISPR, scientists at Washington University School of Medicine in St. Louis have shed light on a rare syndrome that causes children to lose the ability to manufacture vital blood cells. The syndrome, dyskeratosis congenita, is characterized by shortened telomeres. Credit: Marquet Minor Using the gene editing technology CRISPR , scientists have shed light on a rare, sometimes fatal syndrome that causes children to gradually lose the ability to manufacture vital blood cells. The research, at Washington University School of Medicine in St. Louis, suggests new lines of investigation into how to treat this condition -- dyskeratosis congenita -- which is characterized by shortened telomeres. Telomeres, the protective caps on the ends of c...

Creation of organoids from stem cells permits scientists to check discrete areas of mind because it develops. Credit score: Courtesy of Yale College Scientists can now discover in a laboratory dish how the human mind develops by creating organoids -- distinct, three-dimensional areas of the mind. In analysis revealed in  Cell Stem Cell , Yale scientists coaxed early stage stem cells to create and fuse two varieties of organoids from totally different mind areas to point out how the creating mind maintains correct steadiness of excitatory and inhibitory neurons. A failure to keep up this steadiness has been implicated in a number of neurodevelopmental issues equivalent to autism and schizophrenia. "The inhibitory neurons migrate from particular areas of the embryonic mind to the area the place excitatory neurons are being produced," stated senior creator In-Hyun Park, affiliate professor ...

Prof Solar Fei and the brand new protein-based hydrogel developed by his workforce. Credit score: Picture Copyright: HKUST A analysis workforce led by Prof SUN Fei, Assistant Professor of Chemical & Organic Engineering at The Hong Kong College of Science and Expertise (HKUST), has created a brand new protein-based stimuli-responsive good hydroge l that might open doorways for future materials biology and biomedical functions. Hydrogels, also called mushy matter within the medical world, are main supplies for biomedical functions equivalent to drug supply and stem cell remedy. However conventional hydrogels, utilized in merchandise equivalent to facial masks and speak to lenses, are made up of both artificial polymers or organic extracts equivalent to animal collagen, are more likely to trigger allergy symptoms. They can't totally mimic the complicated organic atmosphere wanted for cell progress an...

Corneal wound healing is a complex process that occurs in response to various eye injuries and surgery. Delayed, incomplete, or excessive healing is a significant clinical concern. The review presents evidence on the participation of stem cells in corneal wound healing and highlights how stem cell transplantation may be used to fine tune wound healing and provide benefits for patients. "The advances in transplant techniques and the range of available cell sources that can be used to optimize the treatment of aberrant corneal wound healing can give reassurance to patients with corneal injuries that preserving vision may be possible in the near future, " wrote the authors of the  Stem Cells  review. for more information visit our product website:  Buy Vidalista 20 mg Online

With the vision of providing a cell therapy for type 1 diabetes patients, scientists at the University of Copenhagen have identified a unique cell surface protein present on human pancreatic precursor cells providing for the first time a molecular handle to purify the cells whose fate is to become cells of the pancreas -- including insulin producing cells. The work, outlined in a landmark study entitled 'Efficient generation of glucose-responsive beta cells from isolated GP2+ human pancreatic progenitors' has just been published in  Cell Reports . A biomarker to clearly separate cell populations is a holy grail of cell therapy research for the reasons of safety and end product consistency. By using this cell surface marker, the researchers have engineered a streamlined and simplified differentiation process to generate insulin-producing cells for future treatment of type 1 diabetes patients. The process enables cost-efficient manufacturing and exploits at its core an int...